ABSTRACT
Objective To investigate the effect of ear massage on blood pressure and sleep quality of hypertensive patients . Methods Two hundred and ninety-eight elderly hypertensive patients were nursed on the basis of conventional therapy. One hundred and forty-eight patients randomly selected were set as the experiment group, where they were given intervention of ear massage. Another one hundred and fifty patients were set as the control group and treated with conventional interventions. The two groups were compared in terms of blood pressure (systolic and diastolic blood pressure) after nursing interventions and the sleep quality (by Pittsburgh sleep quality index, PSQI). Result After intervention, the diastolic and systolic blood pressure values in the experiment group were both significantly decreased than before intervention (P<0.05) and the quality of sleep was significantly lower than that before intervention (P<0.05). Conclusion Ear massage can be effective in regulating blood pressure in elderly hypertensive patients and improving their quality of sleep.
ABSTRACT
Objective To investigate the effect of nobiletin,a citrus polymethoxy flavonoid,on hepatocarcinoma Heps in mice and to explore its immunological mechanism.Methods Mice tumor models were made by transplantation of Heps hepatocarcinoma cell strain.The tumor mass was weighed to calculate the tumor-inhibitory rates.The whole cellular immunity was observed by delayed type hypersensitivity(DTH).MTT assay was used to detect the proliferation of T and B lymphocyte,and the activities of cytotoxic T lymphocytes(CTL) and natural killing cells(NKC) were measured by lactate dehydrogenase(LDH) releasing method.Results Nobiletin could markedly inhibit the growth of hepatocarcinoma Heps(solid tumor).The decreased DTH in hepatocaricinoma mice was enhanced significantly,and T and B lymphocyte proliferation were increased by nobiletin.Meanwhile,the killing activities of CTL and NKC were promoted obviously.Conclusion Improvement of the immune function may be a vital route of nobiletin in inhibiting the proliferation of hepatocarcinoma Heps in mice.